IGF-1 LR3

Description

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1)

Overview: IGF-1 LR3 is a laboratory-made analogue of human IGF-1. It features two modifications: an arginine substitution at position 3 (Arg3 instead of Glu3) and the addition of 13 amino acids to the N-terminus. This results in an 83-amino-acid peptide (versus 70 in native IGF-1) with greatly increased stability, potency, and reduced binding to IGF-binding proteins (IGFBPs).

Mechanism of Action

IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), triggering intracellular pathways such as PI3K/AKT and MAPK. These pathways regulate cell growth, survival, protein synthesis, and glucose uptake. Because LR3 binds poorly to IGFBPs, it remains more available to activate receptors, making it more potent and longer-lasting than native IGF-1.

Pharmacokinetics — Why LR3 Is “Long”

The structural modifications extend IGF-1 LR3’s circulating half-life to approximately 20–30 hours (varies by model), compared with much faster clearance of native IGF-1. Reduced binding to IGFBPs further enhances receptor exposure and biological effect.

Metabolic Effects

IGF-1 signaling enhances glucose uptake in muscle and can lower blood glucose acutely, giving it insulin-like properties in addition to its growth-promoting actions.

Research and Preclinical Evidence

• Therapeutic interest: IGF-1 analogues have been studied in the context of growth, tissue repair, and metabolic regulation.
• Preclinical data: In vitro and animal studies demonstrate potent anabolic and tissue-growth effects of IGF-1 LR3.

Bottom Line

IGF-1 LR3 is a long-acting, more potent analogue of native IGF-1. Research shows extended activity and robust anabolic effects, making it a valuable tool for laboratory investigation.

Research Use Only: IGF-1 LR3 is supplied strictly for laboratory and research purposes. It is not approved for human consumption, medical, or veterinary use.

Product Specifications

• Form: Lyophilized powder
• Purity: ≥99% (HPLC)
• Quantity: 1 mg per vial
• Molecular Weight: 9,111 Da
• CAS Number: 946870-92-4
• Solubility: Soluble in bacteriostatic or sterile water for laboratory preparation
• Characterization: Identity and purity confirmed by HPLC and mass spectrometry
• Testing: Independent third-party analytical verification

Storage and Handling

Lyophilized IGF-1 LR3 should be stored at -20°C and protected from light and moisture. Once reconstituted in a laboratory setting, the solution is best kept refrigerated at 2°C to 8°C and used within a short working window. Handling should follow standard laboratory safety practices, including the use of appropriate personal protective equipment. This material is intended for qualified research personnel only.

Disclaimer, Intended Use & Terms of Sale

All content and information provided are for educational and research reference purposes only. This product and its associated data have not been evaluated by the U.S. Food and Drug Administration, and no claims are made regarding the diagnosis, treatment, cure, or prevention of any disease. No representations or warranties are made regarding safety, effectiveness, or outcomes.

This product is intended strictly for in vitro laboratory research use only and is not for clinical use. It is not approved for human or animal administration and must not be used in food, dietary supplements, pharmaceuticals, cosmetics, or any consumer applications.

By purchasing from Alpha One Nutrition, the buyer affirms that they are a qualified researcher or institution with the appropriate training and facilities to handle research compounds in compliance with all applicable laws and regulations. All sales are final.